Participants receive a phone call at baseline, after six months and at annual visits for three years after that as opposed to a call at baseline only.
Frequency of telephone contact may increase retention.
An increase of 6% (95% confidence interval = -5% to 17%).
GRADE Low certainty.
We recommend that trialists consider keeping up regular phone contact with participants.
See Resource bundle below for details on how to implement frequent telephone contact.
Imagine initial retention is 65% of those approached. You have a trial with 100 participants that needs responses from 80 to meet its statistical power calculations. Retention of 65% means that you will be 15 responses short (see chart below).
Now imagine using frequent telephone contact. The chart below shows the impact of an absolute increase of 6% (95% CI = -5% to 17%). Retention is now 71%, which means our best estimate is that you would now only be 9 responses short.
Trial Forge will make trials more efficient by looking for marginal gains across all trial processes, from research question to implementation into routine care. It will encourage everyone connected with trials to be more sceptical of what we do by asking for the evidence behind all of our trial decisions.