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Prenotification cards (ID RET18)

Evidence Summary

What is it?

Participants are contacted to let them know that the trial team will be sending a questionnaire to them soon.

Does it work?

Prenotification cards may increase retention slightly.

How big is the effect?

An increase of 3% (95% confidence interval = -3% to 10%).

How certain are we?

GRADE Low certainty.


We recommend that trialists consider using pre-notification cards.

How can I use this straight away?

See Resource bundle below for details on how to use prenotification cards.

Practical Impact

Imagine initial retention is 65% of those approached. You have a trial with 100 participants that needs responses from 80 to meet its statistical power calculations.  Retention of 65% means that you will be 15 responses short (see chart below).

Now imagine using prenotification cards. The chart below shows the impact of an absolute increase of 3% (95% CI = -3% to 10%). Retention is now 68%, which means our best estimate is that you would now be only 12 responses short.

Cumulative Meta-Analysis*

*Random effects model done using Comprehensive Meta-Analysis v4 ( Differences >0% favour the intervention. The GRADE assessment is low because of the imprecision of a single study and a wide CI crossing RD=0.

Resource Bundle

How to Cite

Citation: Ostrovska B. Evidence pack– Retention: Prenotification cards (RET18), 2023,

More Information

  1. This summary is from the Cochrane review of strategies to improve retention in randomised trials (
  2. The ‘Does it work?’ statement is structured according to effect size and GRADE certainty as per GRADE Guidelines 26 ( The statement is for small effect size and Low GRADE certainty.
  3. The recommendation statement is the consensus view of the authors of this summary based on the GRADE certainty and features of the trials contributing to the evidence.
  4. If you have any questions contact
v1.0 - 06/07/2023
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