Identifying Trial Sites

Often an underestimated task, site identification and selection are among the most significant factors for the completion of a successful clinical trial. When identifying potential trial sites consideration must be given to basic trial needs such as the availability of specialised diagnostic or therapeutic equipment where necessary. Geographic location and regulatory history should also be taken into account in the same manner as contractual and budgetary restrictions. More subjective factors to consider may include a site’s track record with previous trials that are in a similar research field or research similar work, and the anticipated rate of participant recruitment.  Site staff are important in the effective running of a trial, so evaluating their motivations and interest in your trial may be a useful factor to bear in mind.

Selecting the ‘wrong’ site may impede trial progress and result in delays and unplanned costs. It is also important to consider the groups of people your trial needs and place trial sites as close to where these people live as possible. This can help improve trial diversity and inclusion by making the trial more accessible to people from different ethnic groups or socioeconomic backgrounds.

We have also developed a tool called ESP, which might help site selection choices.  It does need more evaluation but you might find it useful.