PeRSEVERE Principles

This table lists the 17 PeRSEVERE Principles, arranged in four groups (PeRSEVERE Project):

O: overarching principles	These guide the overall approach to preparing for and managing participation changes in clinical trials and other research.	O1: participation can stop, reduce or change O2: participants decide how their participation changes O3: the more data, the better O4: losing contact O5: continuing data collection O6: retaining data O7: information after stopping participation
D: study development and participant information	These cover aspects of clinical trial setup, including providing clear information to potential participants.	D1: protecting study integrity by design D2: protocol content D3: participant information about stopping participation D4: participant information about losing contact D5: encouraging dialogue D6: training and support
M: data management and monitoring	Ensuring good quality data is collected about participation changes, and using that data to oversee what’s happening in each trial.	M1: informative data collection about participation changes M2: monitoring
R: study analysis and reporting	Ensuring each trial’s analysis has the best chance of reaching a reliable results, and producing clear trial reports.	R1: analysing studies with participation changes R2: consistent and complete reporting