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Trial Diversities

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PRO EDI: improving how equity, diversity and inclusion are handled in evidence synthesis

Equity, diversity and inclusion in evidence synthesis Few single randomised trials change practice, and this is how it should be.  Instead, bodies of evidence from several trials are collated through evidence synthesis, generally systematic reviews.  It is the results of these reviews that lead to practice and guideline changes.  Because evidence synthesis can have important […]

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How to include people with impaired capacity to consent in trials

Ethical medical research relies on the principle of informed consent. However, obtaining valid consent can be difficult in certain situations. For instance, some individuals may find themselves unable to provide consent due to sudden impairing medical conditions like strokes or conditions that cause a gradual loss of capacity, such as dementia. Additionally, individuals with profound

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How to include socioeconomically disadvantaged people in trials

Also see the NIHR INCLUDE Socioeconomic Disadvantage Framework.  Socioeconomic status is a measure of an individual’s social standing, determined by a combination of factors such as education, income, and occupation. People who are socioeconomically disadvantaged experience less favourable social and economic conditions compared to the majority in their society. This disadvantage is multifaceted and can

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How to consider sex and gender in trials

Beyond sex-specific organs, there are numerous disease and treatment-related differences between sexes. Unfortunately, historically, research has heavily relied on male participants, leading to the common practice of extrapolating results and assuming applicability to female patients. This approach can be misleading and potentially harmful with female patients experiencing higher rates of adverse drug reactions and having

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How to collect ethnicity data

The INCLUDED (INCLUsivity through improving the practice anD utility of Ethnicity Data collection in trials) project aimed to find out how data on ethnicity are being collected and handled in clinical trials, what those from diverse ethnic groups think about this, whether this has any bearing on their participation in research, and how the data

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