Trial Diversities

Download the report Download our report by clicking here Our eight recommendations to strengthen partnerships between researchers and diverse ethnic communities are shown in brief in the picture below. The full text of our recommendations is available here.  The Evidence to Decision Framework we used to collate our findings, and support the recommendations is available here. […]

Equity, diversity and inclusion in trials and evidence synthesis Few single randomised trials change practice, and this is how it should be.  Instead, bodies of evidence from several trials are collated through evidence synthesis, generally systematic reviews.  It is the results of these reviews that lead to practice and guideline changes.  Because evidence synthesis can

Also see the NIHR INCLUDE Impaired Capacity to Consent Framework. Ethical medical research relies on the principle of informed consent. However, obtaining valid consent can be difficult in certain situations. For instance, some individuals may find themselves unable to provide consent due to sudden impairing medical conditions like strokes or conditions that cause a gradual

Also see the NIHR INCLUDE Socioeconomic Disadvantage Framework.  Socioeconomic status is a measure of an individual’s social standing, determined by a combination of factors such as education, income, and occupation. People who are socioeconomically disadvantaged experience less favourable social and economic conditions compared to the majority in their society. This disadvantage is multifaceted and can

Beyond sex-specific organs, there are numerous disease and treatment-related differences between sexes. Unfortunately, historically, research has heavily relied on male participants, leading to the common practice of extrapolating results and assuming applicability to female patients. This approach can be misleading and potentially harmful with female patients experiencing higher rates of adverse drug reactions and having